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If you are truly hypothyroid, discontinuing your thyroid medication for a longer period of time can have serious consequences. You should call the doctor to double check, but if should be fine. They symptoms are easy enough to identify if your tsh gets too low. ETA my daughter was on synthroid for mild hypothyroidism until recently Everyone is different, so it's impossible to how to get synthroid prescription say how long one could actually live without thyroid hormones. You should also make sure you have the medication level checked every 3 months, or whenever your doctor tells you to come back because you will likely have symptoms if the level is off either way. Org and it will tell you all of the systems it helps regulate. Have been off synthroid for 3 weeks; 3 weeks left before screening. I'm concerned how serious this could effect me Answer (1 of 11): How long can a body survive without thyroid hormones? However, must you happen to miss a Synthroid (thyroxine) dose it’s best to require it as soon as you bear in mind, unless it’s nearly time for an additional dose.. A person can go for many years without thyroid hormones. I asked if they could get me a refill and they said no. Votes: +2 LI Lizard71 4 Aug 2016. Anyways to make a long story short, I had a total thyroidectomy and have been taking synthroid 100mcg (was just dropped down from 112mcg). I ended up having to go 9 days without it. If someone were to have a total thyroidectomy ( removal of all the thyroid gland), it would take weeks or months for the levels of thyroid hor. The body can survive for many years without a thyroid gland. It is suggested that you just follow the intake dosage and time schedule your personal health care specialist has provided. Indeed, people often go undiagnosed for decades despite suffering from hypothyroid symptoms. How does it take in nutrition meanwhile without the homones? If your levels are normal, I’d think that a week or two shouldn’t be a big deal. Was wondering how long the body can sustain life without hormone therapy. Any longer than 10-12 hours after your last dose, skip it for that day and take it on your normal schedule the next day You can look up the thyroid in wikipedia. I called the pharmacy and got no answers from them either. Within a few days to weeks, you can expect symptoms of hypothyroidism, including: Fatigue Brain fog Depression and/or anxiety Constipation Dry skin and hair Hair loss Weight gain.